In the trial, 67% of the patients received anti-PD-X therapy and chemotherapy . Credit: kalhh from Pixabay.

Immutep has reported positive final data from Part B of the TACTI-002 Phase II trial in second line metastatic non-small cell lung cancer (NSCLC) patients refractory to anti-PD-(L)1 therapy.

The results showed that all the 36 patients, who took part in the trial, demonstrated progression after standard of care first line treatment with anti-PD-X therapy.

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This included 67% of the patients who received anti-PD-X therapy and chemotherapy. This figure rose to 72% when non-evaluable patients were excluded.

In these PD-X refractory, 2L metastatic NSCLC patients, the chemo free combination of efti plus pembrolizumab attained 9.9 months of median Overall Survival (mOS) and a 39% OS rate at 21 months, which compare positively to the usual six to nine months mOS and a 10-15% OS rate at 21 months for standard-of-care chemotherapy.

It was also found that the combination of efti and pembrolizumab was well tolerated by the patients with no new safety signals observed.

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In addition, Immutep conducted tumour growth kinetics (TGK) analysis based on the difference of the sum of the largest diameters of target lesions in the pre- and post-baseline context on patients.

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The analysis found that 83.3% of patients showed decrease or deceleration of tumour growth.

A total of 36%, 39%, and 16.7% of patients had a PD-L1 tumour proportion score (TPS) of less than 1%, 1-49%, and more than 50%, respectively, while 8.3% of patients could not evaluated for PD-L1 expression.

Immutep CEO Marc Voigt said: “These encouraging results and overall survival trends in patients refractory to PD-1/PD-L1 containing therapy, which have confirmed progression via two consecutive scans, offers a potential therapeutic pathway for many in dire need of new options.”