IMNN-001 along with bevacizumab is intended for the treatment of advanced ovarian cancer. Credit: Chinnapong / Shutterstock.

Imunon has started treating the first patient in a Phase I/II clinical trial of IMNN-001, along with bevacizumab in advanced ovarian cancer.

The University of Texas MD Anderson Cancer Center’s Gynecologic Oncology and Reproductive Medicine professor Amir Jazaeri is the principal investigator of the study.

Go deeper with GlobalData

Premium Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

The study plans to enrol 50 patients with stage III/IV advanced ovarian cancer receiving frontline neoadjuvant therapy.

They will be randomised into a 1:1 ratio to receive either standard chemotherapy plus bevacizumab or chemotherapy plus bevacizumab and IMNN-001.

The detection of minimal residual disease (MRD) by second-look laparoscopy (SLL) is the primary endpoint while progression-free survival is the secondary endpoint of the study.

See Also:

Initial SLL data are expected within one year and final PFS results are anticipated nearly three years after enrolment concludes.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

In addition, the study will include a wealth of translational endpoints for understanding the clonal evolution along with immunogenomic features of the MRD phase of ovarian cancer.

The Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology will participate in translational analyses.

During this period, trial samples and animal models of ovarian cancer MRD including genomic and biomarker analyses will be used.

IMUNON president and CEO Dr Corinne Le Goff said: “This new trial testing the combination of IMNN-001 and bevacizumab in ovarian cancer starts as we have just announced very encouraging interim data for our OVATION 2 programme evaluating the benefits of IMNN-001 in the neoadjuvant setting.

“We believe the combination of IMNN-001 and bevacizumab holds promise based on findings in our earlier pre-clinical animal studies, where the combination showed strong synergies.

“IMNN-001 as an innovative immunotherapy may transform the current ovarian cancer first-line treatment landscape and provide new options to women diagnosed with Stage III/IV disease who face low cure rates of 15% or less.”