The trial will support the subsequent clinical development of the inhibitor in indications, including psoriasis and atopic dermatitis. Credit: Martin Trotter / Flickr (Creative Commons).

Innovent Biologics and UNION therapeutics have announced the first participant dosing in a Chinese Phase I study of a next-generation PDE4 inhibitor, orismilast (IBI353).

The multiple dose escalation Phase I study has been designed to assess the safety, tolerability, and pharmacokinetic (PK) profile of orismilast in healthy Chinese participants after giving multiple doses of a PDE4 inhibitor.

Go deeper with GlobalData

Premium Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

This will support the subsequent clinical development of the inhibitor in several indications, including atopic dermatitis (AD) and psoriasis.

Orismilast has a high potency for the PDE4 subtypes connected to inflammation.

Last year, the company entered into a strategic cooperation with UNION therapeutics for the exclusive rights of orismilast to research, develop, and commercialise in China, including Hong Kong, mainland China, Macao. and Taiwan.

See Also:

Innovent Clinical Development vice-president Dr Lei Qian said: “There is currently no cure for psoriasis, and there is a great unmet clinical need in this field.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

“The results of ex-China clinical studies have demonstrated that orismilast has a good safety profile and biological activity.

“We will accelerate the clinical development of orismilast in Chinese subjects with psoriasis or AD in order to obtain regulatory approval as soon as possible in China and to fulfil the needs of safe, effective, and convenient long-term oral treatment for patients, thus significantly reducing the disease burden of patients and their pain.”

The company stated that the PDE4 inhibitor has generated positive proof of concept (PoC) data in psoriasis, when given orally, and in AD, when given topically.

Orismilast is currently being developed as a potential best- or first-in-class oral therapy option for psoriasis and AD.