Janux Therapeutics has dosed the first patient at the City of Hope, US, in a Phase I trial of JANX008, designed to treat patients with advanced or metastatic solid tumours.
JANX008 will be evaluated in patients with these tumours, and including colorectal cancer, non-small cell lung cancer, squamous cell carcinoma of the head and neck, and renal cell carcinoma.
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The open-label, multicentre dose escalation and dose expansion study will investigate the safety, tolerability, pharmacokinetic and pharmacodynamic properties of JANX008.
It will assess the preliminary anti-tumour activity of JANX008 in adult subjects with advanced or metastatic carcinoma expressing epidermal growth factor receptor (EGFR).
Janux CEO and president David Campbell said: “JANX008 is the second therapeutic from our TRACTr platform to enter a first-in-human clinical trial, demonstrating the potential of our platform and the commitment of our team to address critical and urgent unmet needs for patients with advanced or metastatic solid tumours.”
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An EGFR-directed T cell engager (TCE), JANX008 uses the company’s TRACTr platform to be administered in humans.
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By GlobalDataJanux chief medical officer Wayne Godfrey said: “JANX008 is designed to achieve tumour-selective T cell activation and tumour killing while sparing healthy tissues.
“Our preclinical data with JANX008 demonstrated tumour growth inhibition and lower toxicity levels when compared to an unmasked T cell engager.”
