After 16 weeks, patients treated with delgocitinib cream reported statistically significant improvement in chronic hand eczema. Credit: Care_SMC / Flickr (Creative Commons).

Leo Pharma has reported positive data from the DELTA 2 trial of delgocitinib cream in moderate to severe chronic hand eczema (CHE).

The second of two pivotal Phase III clinical trials, the DELTA 2 trial has been designed for evaluating the efficacy of twice-daily delgocitinib cream against cream vehicle for a 16-week treatment period in adult patients.

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Findings showed that the trial met its primary and important secondary endpoints, which confirmed the positive results of the DELTA 1 trial.

Patients treated with delgocitinib cream showed statistically significant improvement in CHE after 16 weeks. It was also found to be well-tolerated.

The cream also provided efficacious treatment and relief in early CHE symptoms.

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Further analyses will be conducted for determining the complete potential of the delgocitinib cream in moderate to severe CHE adult patients.

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LEO Pharma Global Research & Development executive vice-president Jörg Möller said: “It is incredibly exciting to see the level of consistency that our DELTA 2 results show in line with the positive DELTA 1 results announced late last year.

“CHE is a condition that we know can have a hugely negative impact on patient quality of life, physical functioning, and ability to work.

“These results bring us one step closer towards establishing delgocitinib as a best-in-class innovative topical treatment for patients affected by this hard-to-treat disease.”

The company stated that the participants who have completed the 16-week treatment in the DELTA 1 or DELTA 2 trials are offered to roll-over to the DELTA 3 extension trial for assessing the cream’s long-term effects.

It intends to later submit the detailed data from the DELTA 2 trial for scientific presentation and publication.