Eli Lilly has reported positive patient-reported outcomes (PRO) from a late-stage trial testing the efficacy of Verzenio (abemaciclib) in treating high-risk early breast cancer (EBC).

The move comes after a primary outcome analysis of the Phase III monarchE trial showed Verzenio in combination with endocrine therapy (ET) reduced the risk of breast cancer recurrence by 28.7% compared with ET alone.

The ongoing multicentre, randomised, open-label study is assessing investigational use of Verzenio in combination with standard adjuvant ET for treating hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) high-risk EBC.

The PRO analysis was based on information procured from both arms of the study. It measured the subjects’ experiences with side effects, symptoms, and other health-related data.

One of the analyses found that nearly 70%-75% of the patients in both arms reported being bothered ‘a little bit’ or ‘not at all’ by treatment-related side effects.

The data indicate that the addition of Verzenio did not result in clinically meaningful difference in patients complaining about treatment side effects.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

The company presented the data at the virtual 17th St Gallen International Breast Cancer Conference.

Dana-Farber Cancer Institute’s Dr Sara M Tolaney said: “The patient-reported outcomes analysis represents another step forward in our understanding of the impact for patients who receive abemaciclib in the early breast cancer setting.

“These important data demonstrate actual patient-reported outcomes, which are the first to be reported for a CDK4 & 6 inhibitor in the early breast cancer setting.

“These analyses continue to reaffirm our confidence in abemaciclib, and its potential to make a difference for those with high risk early breast cancer.”

Lilly recently released detailed results of a Phase II TRAILBLAZER-ALZ study conducted to determine the efficacy of investigational antibody donanemab for treating Alzheimer’s disease.