View all newsletters
Receive our newsletter - data, insights and analysis delivered to you
  1. News
May 13, 2021updated 12 Jul 2022 11:18am

Magenta’s multiple myeloma treatment trial meets primary endpoint 

Magenta’s Phase II trial of MGTA-145 for multiple myeloma treatment meets the primary endpoint.

Magenta Therapeutics has reported that Phase II clinical trial of MGTA-145 in combination with plerixafor in multiple myeloma patients met the primary endpoint.

Free Case Study
img

Direct-to-Patient Trials: How IRT Plays an Important Role in Bellerophon's Direct-to-Patient Trials

As the industry strengthens its focus on patient centricity, Direct-to-Patient clinical trials have emerged as a popular trial design that have the potential to increase patient recruitment and retention. IRT plays a crucial role in the success of a Direct-to-Patient trial. Because drug supplies are being managed and shipped from distribution facilities directly to patients’ homes, a sponsor must have a high-quality system in place to accurately track the chain of custody, ensure patient-blinding and handle other logistical challenges. What You Will Learn Benefits and challenges associated with the Direct-to-Patient model Bellerophon's top considerations when implementing this trial design How IRT can equip study teams to successfully track chain of custody, ensure patient blinding, and handle logistical challenges
by Suvoda
Enter your details here to receive your free Case Study.

All ten subjects met the primary goal of mobilising two million CD34+ stem cells per kg in up to two days of same-day mobilisation and apheresis, preliminary results showed.

The investigator-initiated, Phase II open-label trial is evaluating whether MGTA-145 plus plerixafor can gather stem cells for autologous stem cell transplant in the trial subjects.

Progressing currently at the Stanford University School of Medicine, US, the trial will enrol a total of 25 participants.

The preliminary data from the trial also showed that nine out of ten subjects met the primary endpoint in a day.

In a day, the median number of stem cells accumulated was 5.4 million CD34+ stem cells per kg.

All six transplanted subjects were found to be effectively engrafted and the median recovery of neutrophils after 12 days and platelets after 17 days were seen to be within anticipated levels in multiple myeloma.

In addition, the MGTA-145 plus plerixafor treatment was found to be well tolerated in the trial.

Magenta Therapeutics president and CEO Jason Gardner said: “A patient’s ability to mobilise is highly contingent on a variety of risk factors, which is particularly relevant for blood cancer patients.

“These initial results provide insight into MGTA-145 plus plerixafor’s ability to improve the approach to mobilisation and collection, and its potential to be a first-line mobilisation drug in this and other disease areas.”

Furthermore, the company is set to submit an Investigational New Drug (IND) application for its MGTA-117 drug candidate next month.

Magenta expects to commence the Phase I/II clinical trial of MGTA-117 for treating patients with relapsed/refractory acute myeloid leukaemia and myelodysplastic syndromes soon.

This dose-escalation trial will assess the safety, pharmacokinetic and pharmacodynamic profile of MGTA-117 as monotherapy.

Related Companies

Free Case Study
img

Direct-to-Patient Trials: How IRT Plays an Important Role in Bellerophon's Direct-to-Patient Trials

As the industry strengthens its focus on patient centricity, Direct-to-Patient clinical trials have emerged as a popular trial design that have the potential to increase patient recruitment and retention. IRT plays a crucial role in the success of a Direct-to-Patient trial. Because drug supplies are being managed and shipped from distribution facilities directly to patients’ homes, a sponsor must have a high-quality system in place to accurately track the chain of custody, ensure patient-blinding and handle other logistical challenges. What You Will Learn Benefits and challenges associated with the Direct-to-Patient model Bellerophon's top considerations when implementing this trial design How IRT can equip study teams to successfully track chain of custody, ensure patient blinding, and handle logistical challenges
by Suvoda
Enter your details here to receive your free Case Study.

NEWSLETTER Sign up Tick the boxes of the newsletters you would like to receive. Key drug pipeline and competitive landscape changes based on the latest clinical activity, sent every Tuesday. Curated analysis and data-driven insights on clinical trials strategy and operations, sent every Thursday. The pharmaceutical industry's most comprehensive news and information delivered every month.
I consent to GlobalData UK Limited collecting my details provided via this form in accordance with the Privacy Policy
SUBSCRIBED

THANK YOU

Thank you for subscribing to Clinical Trials Arena