The trial will assess the safety and immunogenicity of the ARCT-154 vaccine in healthy adult subjects aged 18 years and above. Credit: torstensimon from Pixabay.

Meijisubsidiary Meiji Seika Pharma has commenced a Phase III clinical trial of a messenger ribonucleic acid (mRNA) vaccine, ARCT-154, for Covid-19 in Japan.

The observer-blind, multicentre, randomised, active-controlled, comparative trial is funded partially by the Ministry of Health, Labour and Welfare of Japan.

Go deeper with GlobalData

Premium Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

It will analyse the immunogenicity and safety of ARCT-154 in healthy adult subjects aged 18 years and above.

The trial will enrol subjects who have previously received three doses of an approved mRNA Covid-19 vaccine, a minimum of three months ago.  

It anticipates enrolling a total of 780 subjects, with 390 each in the ARCT-154 and Comirnaty arms.

See Also:

In the trial, a 5µg intramuscular dose of ARCT-154 will be given to trial subjects.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

The trial, which started in November this year, will continue until April 2024.

Developed by Arcturus Therapeutics, ARCT-154 is claimed to be effective against SARS-CoV-2 viral variants, including the Omicron variant.

In addition, the vaccine could require a low vaccination dosage and have long-lasting effects.

Meiji also has plans to set up a domestic production system, using a subsidy from the Ministry of Economy, Trade and Industry.

In April this year, the company dosed the first subject in a Phase II clinical trial of a selective phosphodiesterase-4 (PDE4) inhibitor, ME3183, in plaque psoriasis patients in the US and Canada.

The double-blind, randomised, placebo-controlled trial was designed to assess the safety, efficacy, and tolerability of ME3183 for 16 weeks.

A total of 125 subjects were planned to be enrolled at nearly 30 US and Canadian sites for this trial.