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May 6, 2021

Moderna’s Covid-19 vaccine booster doses increase antibody responses

Moderna has reported initial data from its Phase II study, which demonstrated that a single 50µg booster dose of its Covid-19 vaccines, mRNA-1273 or mRNA-1273.351, enhanced neutralising antibody titer responses in previously inoculated people.

The responses were observed against the SARS-CoV-2 virus and two variants of concern, the B.1.351 variant, which was first detected in South Africa, and the P.1 variant found in Brazil.

The mRNA-1273 Covid-19 vaccine is authorised for emergency use for active immunisation to prevent Covid-19 in adults, while mRNA-1273.351 is a booster vaccine candidate based on the B.1.351 variant.

A multivalent booster candidate called mRNA-1273.211, a combination of mRNA-1273 plus mRNA-1273.351, is also being evaluated.

The Phase II study is assessing three ways for increasing neutralising titers in already vaccinated subjects using mRNA-1273.351, mRNA-1273.211 and 50µg mRNA-1273 booster dose.

Data from the trial showed that mRNA-1273.351 booster dose provided increased neutralising antibody titers against the B.1.351 variant than mRNA-1273 booster dose.

Furthermore, safety and tolerability profiles on administering a third booster dose of 50µg mRNA-1273 or mRNA-1273.351 were in line with those noticed following second mRNA-1273 dose in earlier trials.

The vaccine boosters were found to be well-tolerated with mild or moderately severe adverse events.

In addition, the mRNA-1273.351 vaccine had a reduced reactogenicity profile as compared to mRNA-1273 in this Phase II trial.

Moderna CEO Stéphane Bancel said: “The strong and rapid boost in titers to levels above primary vaccination also clearly demonstrates the ability of mRNA-1273 to induce immune memory.

“Our mRNA platform allows for rapid design of vaccine candidates that incorporate key virus mutations, potentially allowing for faster development of future alternative variant-matched vaccines should they be needed.”

Data from the analysis of mRNA-1273.211 is anticipated soon, the company noted.

Parallelly, the National Institutes of Health unit National Institute of Allergy and Infectious Diseases is carrying out a Phase I study of mRNA-1273.351 vaccine.

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