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Biopharmaceutical company AbbVie has presented data from the SURVEYOR studies of ABT-493, an NS3/4A protease inhibitor, and ABT-530, an NS5A inhibitor.

ABT-493 is the result of an ongoing partnership between AbbVie and Enanta Pharmaceuticals for HCV protease inhibitors and regimens, including protease inhibitors.

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The inhibitor is being developed for use in combination with AbbVie’s other investigational medicines for the treatment of hepatitis C.

At 12 weeks post-treatment (SVR12), the data showed high rates of sustained virologic response in non-cirrhotic patients with chronic hepatitis C virus (HCV) infection.

SVR12 rates were 97-100% in genotype 1 (GT1), 96-100% in genotype 2 (GT2) and 83-94% in genotype 3 (GT3) patients after 12 weeks of treatment.

In the SURVEYOR-I study non-cirrhotic GT1 chronic HCV patients, who received a shorter eight-week treatment, achieved an SVR12 rate of 97%.

AbbVie chief scientific officer Dr Michael Severino said: "The SURVEYOR trials offer important new information about the potential to treat patients with chronic hepatitis C across multiple genotypes with our two direct-acting antiviral investigational regimen.

"AbbVie’s ongoing hepatitis C research program demonstrates our commitment to make a remarkable impact on the lives of HCV patients."

SURVEYOR-I and SURVEYOR-II are ongoing Phase II clinical studies to assess the safety and efficacy of ABT-493 and ABT-530, with or without ribavirin (RBV), for eight to 12 weeks.

According to AbbVie, data in non-cirrhotic patients with GT4, GT5, and GT6 chronic HCV infection will be presented in the near future.

A multinational Phase III programme, initiated earlier in November, will evaluate ABT-493 and ABT-530 in genotypes 1 through 6.

Image: Electron micrographs of hepatitis C virus purified from cell culture. Photo: courtesy of Charles Rice / Center for the Study of Hepatitis C, The Rockefeller University.