US-based clinical-stage biopharmaceutical company BeiGene has begun its Phase I clinical trial of BGB-290 in China to treat advanced solid tumours.

BGB-290 is a highly selective inhibitor of Poly (ADP-ribose) polymerase (PARP1) and PARP2 that is being developed as a monotherapy and in combination with other therapies to treat cancers such as ovarian cancer, prostate cancer, breast cancer, glioblastoma multiforme, small-cell lung cancer and gastric cancer.

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It has exhibited favourable PARP1 and PARP2 selectivity in biochemical assays, as well as demonstrated improved specificity.

The Phase I trial is being conducted as an open-label, multi-centre dose escalation and expansion study of BGB-290 intended to determine safety, pharmacokinetics, and anti-tumour activity of BGB-290 in Chinese patients diagnosed with advanced solid tumours.

"We look forward to developing BGB-290 for patients in China, where this class of agents is still not available."

The trial will also determine the recommended dose for Phase II patients. 

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Professor Binghe Xu from The Chinese Academy of Medical Sciences Cancer Hospital is acting as the study's principal investigator.

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Beigene founder and CEO John Oyler said: “We are pleased to announce the start of clinical development for BGB-290 in China, and we look forward to its rapid development following this Phase I study. 

"BGB-290 entered clinical evaluation in Australia in July 2014, and proof of principle data were presented at the AACR-NCI-EORTC meeting in 2015. 

"We look forward to developing BGB-290 for patients in China, where this class of agents is still not available."