Israeli-based BioLineRx has started its Phase IIa COMBAT trial of BL-8040 in combination with KEYTRUDA (pembrolizumab) to treat metastatic pancreatic cancer.

BL-8040 is a short peptide designed to inhibit CXCR4, a chemokine receptor considered responsible for tumour progression, angiogenesis, metastasis and cell survival.

Go deeper with GlobalData

Data Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

Merck’s humanised monoclonal antibody Keytruda boosts the body's immunity system to detect and fight tumour cells.

It resists PD-1 from interacting with its ligands, PD-L1 and PD-L2, subsequently activating T-lymphocytes, which may affect both tumour and healthy cells.

The Phase IIa COMBAT trial has been designed as an open-label, multicentre, single-arm study intended to assess the safety, efficacy, tolerability and multiple pharmacodynamic parameters of the combination of BL-8040 and KEYTRUDA.

See Also:
"The study is a result of immunotherapy collaboration between BioLineRx and Merck and will involve 30 patients with metastatic pancreatic adenocarcinoma."

The study is a result of immunotherapy collaboration between BioLineRx and Merck and will involve 30 patients with metastatic pancreatic adenocarcinoma.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

BioLineRx chief financial and operating officer Philip Serlin said: "We are looking forward to conducting this combination study of our lead oncology product and MSD's immune checkpoint inhibitor, which will be the first study of BL-8040 in the exciting and promising field of cancer immunotherapy.

“We believe that the combination of BL-8040 with KEYTRUDA has the potential to expand the benefit of immunotherapy to cancer types currently resistant to immuno-oncology treatments, such as pancreatic cancer, which represent a significant unmet medical need."

Clinical and pre-clinical studies have validated the efficacy of BL-8040 in classifying cancer cells from the bone marrow and exposing them to chemo-based and bio-based anti-cancer therapy.

Image: Axial CT image displays macrocystic adenocarcinoma of the pancreatic head. Photo: courtesy of MBq.