bluebird bio has started treating patients in a Phase I clinical trial (CRB-402) of its investigational candidate bb21217 for relapsed or refractory multiple myeloma.

bb21217 is a chimeric antigen receptor T cell (CAR T) therapy being developed in partnership with Celgene to target B cell maturation antigen (BCMA).

Go deeper with GlobalData

Data Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

Under the collaboration, Celgene has exercised its option to exclusively licence bb21217 and will make a $15m option exercise payment to bluebird bio.

The Phase I trial will include a dose-escalation portion during, which patients will be administered with increasing doses of bb21217 to establish a maximum tolerated dose and recommended Phase II dose.

“bb21217 complements bb2121, which has demonstrated encouraging safety and efficacy results in an ongoing Phase I trial.”

A dose expansion portion is also included in the trial for further assessment of bb21217’s safety, tolerability, and clinical activity when given at the recommended Phase II dose.

bluebird bio chief scientific officer Philip Gregory said: “bb21217, bluebird’s second oncology programme to enter the clinic, complements bb2121, which has demonstrated encouraging safety and efficacy results in an ongoing Phase I trial.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

“With bb21217, we manufacture a CAR T cell product enriched for memory T cells, a long-lived, more potent T cell subtype, which in preclinical in vivo studies has shown improved anti-tumour activity.”

The CRB-402 trial’s primary objective is an evaluation of the maximum tolerated dose and determination of the recommended Phase II dose, while the secondary objective is a measurement of preliminary efficacy data.

Following the Phase I trial, Celgene will be responsible for bb21217’s world-wide development and commercialisation.