Encap Drug Delivery has collaborated with Lena Nanoceutics to develop Nano-Capsules, a new drug delivery technology that integrates Lena's proprietary nano-particle engineering technology with Encap's liquid-filled hard capsule technology.
Preliminary in vitro data produced using itraconazole revealed that both nano-particulate and liquid fill formulations have an improved dissolution rate compared with standard particulate drug formulations.
When the two were combined, a greater improvement was seen.
Liquid-fill formulations can be solutions or suspensions of drug in non-aqueous liquids, found to generate increased bioavailability of the active drug.
The nano-capsule technology results in a decrease in particle size and an increased surface area, hence a faster dissolution.