US-based clinical-stage oncology company G1 Therapeutics has collaborated with Genentech to conduct a Phase II clinical trial of tecentriq and trilaciclib to treat patients with small-cell lung cancer (SCLC) receiving chemotherapy.
G1’s trilaciclib (G1T28) is a short-acting intravenous CDK4/6 inhibitor that is being developed to sustain hematopoietic stem cells and enhance immune system function during chemotherapy.
Genetech’s tecentriq is an anti-PD-L1 monoclonal antibody that binds to PD-L1 expressed on tumour cells and tumour-infiltrating immune cells, thereby inhibiting its interactions with both PD-1 and B7.1 receptors.
G1 Therapeutics CEO Mark Velleca said: “We are excited that this combination regimen of trilaciclib plus Tecentriq may benefit patients with small-cell lung cancer, a disease with tremendous unmet medical need.
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“Trilaciclib has demonstrated its ability to preserve the immune system from damage by chemotherapy and to enhance T-cell activation, which may augment anti-tumour immunity and be a powerful complement to Tecentriq.”
Expected to commence next year, the drug combination will be applied as a first-line treatment for small-cell lung cancer patients.
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Trilaciclib has demonstrated its anti-tumour activity, including a complete response and multiple partial responses, while applied in combination with chemotherapy to patients with SCLC during two ongoing Phase Ib/IIa trials.
The treatment was favourably tolerated, with no occurrence of febrile neutropenia.
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