US-based biopharmaceutical company Ligand has reported positive data from two Phase I trials reports of LGD-6972 to treat type 2 diabetes.

LGD-6972 is Ligand’s glucagon receptor antagonist, which activates a non-insulin mechanism to lower plasma glucose in type 2 diabetic patients.

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The Phase Ia and Phase Ib trials were designed as single and multiple-dose, randomised, double-blind and placebo-controlled studies to determine the safety, tolerability and pharmacokinetics profile of LGD-6972 when administered to healthy subjects and patients with type 2 diabetes mellitus.

LGD-6972 was administered in single or multiple oral doses.

"LGD-6972 is Ligand’s glucagon receptor antagonist, which activates a non-insulin mechanism to lower plasma glucose in type 2 diabetic patients."

Results indicated the efficacy of the glucagon receptor antagonist in lowering fasting plasma glucose within both the healthy subjects and type 2 diabetes patients, recording an increase in insulin and a decrease in glucagon responding to an oral glucose load.

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The study data also suggested the safety and tolerability of LGD-6972, recording no dose-dependent changes in hematology, clinical chemistry or urinalysis panels, electrocardiography or vital signs and no hypoglycemic event.

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Ligand CEO John Higgins said: “These clinical results are encouraging as they demonstrate a favourable safety profile for LGD-6972 and show a robust glycemic response in both healthy subjects and subjects with diabetes."

The company is planning to start a Phase II trial to demonstrate additional safety and efficacy data of LGD-6972.

The trial will be designed as a randomised, double-blind, multicentre study and include 148 patients whose blood glucose levels are inadequately controlled with metformin.