Swiss drug-maker Novartis has reported positive results from two of its pivotal Phase III trials (FUTURE 1 and FUTURE 2) of an investigational medicine secukinumab (AIN457) in patients with psoriatic arthritis (PsA).

Secukinumab works by stopping the action of interleukin-17A (IL-17A), a protein that is central to the development of inflammatory diseases.

Go deeper with GlobalData

Premium Insights

The gold standard of business intelligence.

Find out more

The company said both the randomised, placebo-controlled, multi-centre FUTURE 1 and FUTURE 2 trials met primary and key secondary endpoints.

The trials were designed to show efficacy of secukinumab in PsA compared to placebo as well as to evaluate safety and tolerability.

"The trials were designed to show efficacy of secukinumab in PsA compared to placebo as well as to evaluate safety and tolerability."

Primary endpoint in the trials was the American College of Rheumatology response criteria (ACR20).

See Also:

The endpoints of these trials are improving signs and symptoms of PsA, including improving peripheral joint disease and preventing joint damage versus placebo, while delivering clear or almost clear skin (PASI 90).

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

The company has enrolled a combined total of more than 1,000 patients in these two Phase III trials.

PsA is a debilitating, long-lasting condition that causes inflammation of joints and skin and affects up to 30% of people with psoriasis across the world.

Novartis Pharmaceuticals global head of Development Vasant Narasimhan said: "Building on the positive data previously reported in psoriasis, we are excited to present the first Phase III results of secukinumab in PsA.

"These positive results are planned to form the basis of a filing application to regulatory authorities in this indication.

"Effective new therapies are urgently needed for newly PsA diagnosed patients and for nearly half of PsA patients who are dissatisfied with or not responding to their current treatments."

The company plans to submit global regulatory applications for secukinumab in PsA in 2015.

In October 2013, the company submitted global regulatory applications for secukinumab to treat moderate-to-severe plaque psoriasis, while approvals are expected in late 2014 or early 2015.