Swiss-based biopharmaceutical company ObsEva has commenced the Phase I clinical programme of OBE022 to treat pre-term labour.

OBE022 is a first-in-class, orally active, small molecule prostaglandin F2alpha (PGF2alpha) receptor antagonist.

The trial will include 70 healthy volunteers to determine the safety and tolerability, pharmacokinetics and pharmacodynamics profile of OBE022 when administered in single ascending and multiple ascending oral dosages.

ObsEva chief scientific officer Jean-Pierre Gotteland said: "The first-in-human study programme is an important step towards the development of our first-in-class, orally active, PGF2alpha antagonist OBE022.

"The programme is designed for evaluating in healthy women the safety, tolerance and pharmacokinetics properties of OBE022, and will be essential for moving to Phase II in 2017."

“This further strengthens our advanced clinical stage product pipeline.

“The programme is designed for evaluating in healthy women the safety, tolerance and pharmacokinetics properties of OBE022, and will be essential for moving to Phase II in 2017."

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Pre-term labour is a serious women's pregnancy health condition, resulting in a premature uterus contractions and causing a premature birth prior to 37 weeks of gestation.

PGF2alpha contracts the myometrium, a muscle tissue of womb, causing metabolites to rise in amniotic fluid before and during labour.

It also triggers enzymes to dilate the cervix and resulting to a membrane rupture.

OBE022 is designed to inhibit the PGF2alpha receptor, thereby safely controlling inflammation.

In previously conducted clinical studies, ObsEva has noted that OBE022 prevent spontaneous uterine contractions in pregnant rats without causing the adverse effects seen when compared with other prostaglandin synthesis inhibitors such as Indomethacin.