French biotechnology company Transgene has begun dosing patients in a Phase II trial of TG4010 in combination with Bristol-Myers Squibb's Opdivo (nivolumab) to treat metastatic non-small-cell lung cancer (NSCLC).

Based on a modified vaccinia virus (MVA), TG4010 is an active immunotherapy designed to express the coding sequences of the MUC1 tumour-associated antigen and the cytokine Interleukin-2 (IL2).

Go deeper with GlobalData

Data Insights

The gold standard of business intelligence.

Find out more

Opdivo is a PD-1 immune checkpoint inhibitor that prevents the PD-1 pathway from suppressing the immune response against tumours.

With plans to enrol approximately 33 patients, the multi-centre Phase II trial will evaluate the TG4010 and Opdivo combination as a second line treatment after failure of one line of platinum-based chemotherapy.

"Today, advanced lung cancer remains a severe disease with a poor prognosis. Major improvements are needed in the therapeutic options available to physicians."

Transgene chief medical officer Maud Brandely said: "We are convinced that the complementary mechanisms of action of TG4010 and Opdivo can enhance response rates, increase the duration of response and extend overall survival in patients.

See Also:

"Today, advanced lung cancer remains a severe disease with a poor prognosis. Major improvements are needed in the therapeutic options available to physicians.”

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

The trial is being conducted in collaboration with US-based UC Davis Comprehensive Cancer Center, and its primary objective is to assess the overall response rate of the combination in stage IV non-squamous NSCLC patients who have progressed after one line of platinum-based chemotherapy.

The trial will also examine secondary endpoints such as progression-free survival (PFS), overall survival (OS), duration of response and safety.

It is expected that the trial's first results will be reported by the end of this year.