Trek Therapeutics (TREKtx) has started a Phase IIa clinical trial of TD-6450, an NS5A inhibitor being developed to treat hepatitis C (HCV).

TREKtx recently secured a worldwide licence from Theravance Biopharma for the development, manufacturing, use, marketing and sale of TD-6450 as a component in HCV products.

Go deeper with GlobalData

Premium Insights

The gold standard of business intelligence.

Find out more

Phase IIa will evaluate faldaprevir (FDV), an HCV protease inhibitor, combined with TD-6450 and ribavirin (RBV) in patients infected with HCV genotype 4.

"We believe that its antiviral activity, in combination with other antivirals, may help improve cure rates."

Theravance Biopharma research and development senior vice-president Mathai Mammen said: "This NS5A inhibitor has shown robust antiviral activity in a Phase I trial in patients with HCV genotype 1, as well as preclinical potency against both wild-type HCV and resistance-associated variants.

"We believe that its antiviral activity, in combination with other antivirals, may help improve cure rates and/or reduce treatment times for appropriate patients.

See Also:

Theravance discovered TD-6450 to have improved antiviral activity against genotype 1 resistance-associated variants (RAV) that are resistant to first-generation NS5A inhibitors.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Multivalent NS5A inhibitor TD-6450 has successfully completed Phase I trials in healthy volunteers and HCV patients.

TREKtx chief medical officer Dr Robert Hindes said: "If safety and efficacy are demonstrated, the goal is to initiate clinical trials in Egypt next year, where the need is enormous."

TREKtx’s objective is to develop affordable and accessible medicines for treating infectious diseases and commercialise them for patients worldwide.