Psoriasis

US-based biopharmaceutical firm XenoPort has started a Phase II clinical trial of its proprietary investigational next-generation fumaric acid product candidate ‘ XP23829’ for treatment of patients with psoriasis.

The multi-centre, randomised, double-blind, placebo-controlled trial is designed to evaluate the efficacy and safety of XP23829 as a potential treatment of patients with moderate-to-severe chronic plaque-type psoriasis.

Go deeper with GlobalData

Premium Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

XenoPort chief medical officer Richard Kim said: "From this Phase II trial, we hope to further our understanding of the efficacy, safety and tolerability of XP23829."

"From this Phase II trial, we hope to further our understanding of the efficacy, safety and tolerability of XP23829."

In addition, the trial is designed to generate information on the effect of dose and treatment duration on potential reduction in psoriatic lesions and modulation of sub-populations of blood immune cells.

Based on enrolment rates of psoriasis studies carried out in the US, XenoPort expects top-line results of the trial in the third quarter of 2015.

See Also:

Approximately 200 subjects are expected to be enrolled in the trial, which will include a screening and washout phase of up to four weeks, a 12-week treatment phase and a four-week post-treatment phase.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

In the trial, eligible patients will be randomised to placebo or one of three treatment arms of XP23829: 400mg or 800mg once-daily or 400mg twice-daily.

The trial’s primary endpoint will examine the percent change in Psoriasis Area and Severity Index (PASI) score from baseline at the end of week 12, while the secondary endpoints will include the proportion of subjects who achieve a reduction of 75% or greater from baseline in PASI (PASI-75) score and subjects who achieve a Static Physicians Global Assessment (sPGA) score of ‘clear’ or ‘almost clear’.

Image: A person’s arm covered with plaque psoriasis. Photo: courtesy of Methoxyroxy.