View all newsletters
Receive our newsletter - data, insights and analysis delivered to you
  1. News
August 30, 2022

NIH awards funding for antifungal treatment trial in children

Researchers will assess if children with uncomplicated candidemia show improvement following antifungal therapy for seven days.

The National Institutes of Health (NIH) has awarded funding worth $9.7m to researchers at Arkansas Children’s Research Institute and Children’s Hospital of Philadelphia in the US for a clinical trial of antifungal therapy in children with uncomplicated candidemia, an invasive fungal disease.

The first-of-its-kind, randomised, controlled trial will analyse whether a briefer course of therapy can treat uncomplicated candidemia in these people.

Under the seven-year project, the scientists will assess if children with this disease show improvement following antifungal therapy for seven days.

This will aid in evaluating if the treatment can be halted at that time or if it needs to be continued for another seven days, which is the existing standard of care.

The research will also help in defining the optimal time of treatment for any invasive fungal diseases in people of any age group.

In the trial, the advantages and consequences of treating uncomplicated candidemia over a shorter period will be analysed.

It will also evaluate if a new molecular biomarker, which is already used to rapidly diagnose invasive candidiasis in children, can show if a briefer course of treatment could be a better option for patients.

The International Pediatric Fungal Network (PFN), a 55-site global research consortium, will be used for the trial.

Arkansas Children’s paediatrician in chief William Steinbach said: “This study will build a foundation for improved guidelines that allow us to treat children more rapidly, reduce the medicine they need, and get them back to thriving quickly.

“The results also will inform future trials in adults and allow us to change guidelines for care of all patients with these diseases.”

Related Companies

NEWSLETTER Sign up Tick the boxes of the newsletters you would like to receive. Key drug pipeline and competitive landscape changes based on the latest clinical activity, sent every Tuesday. Curated analysis and data-driven insights on clinical trials strategy and operations, sent every Thursday. The pharmaceutical industry's most comprehensive news and information delivered every month.
I consent to GlobalData UK Limited collecting my details provided via this form in accordance with the Privacy Policy


Thank you for subscribing to Clinical Trials Arena