Nordic presents new Phase l/ll data of Betalutin

12th December 2017 (Last Updated December 12th, 2017 00:00)

Nordic Nanovector has unveiled updated results from its LYMRIT 37-01 Phase l/ll clinical trial of Betalutin (177Lu-satetraxetan-lilotomab) to treat patients with relapsed/refractory (R/R) indolent NHL (iNHL) and third-line follicular lymphoma (3L FL).

Nordic Nanovector has unveiled updated results from its LYMRIT 37-01 Phase l/ll clinical trial of Betalutin (177Lu-satetraxetan-lilotomab) to treat patients with relapsed/refractory (R/R) indolent NHL (iNHL) and third-line follicular lymphoma (3L FL).

The updated data showed that single-agent of Betalutin has been able to reduce the tumour size of 90% of the patients (59) enrolled in the study.

The trial has witnessed 60% overall response rate (ORR) and 24% complete response (CR) for all evaluable iNHL patients.

Betalutin was also found to be highly active in patients with two or more prior therapies including 3L FL with 66% ORR and 25% CR.

In addition, the treatment was well-tolerated with a safety profile characterised by reversible transient neutropenia and thrombocytopenia, as well as a low number of infections.

"The CRs seen in both arm one and arm four in FL patients and the duration of responses are very promising."

LYMRIT 37-01 Phase l/ll study principal investigator Dr Arne Kolstad said: “The combination of efficacy, tolerability and the convenience of a single administration highlight Betalutin’s potential in this primarily elderly, heavily pre-treated patient population.

“Notably, the CRs seen in both arm one and arm four in FL patients and the duration of responses are very promising, and we look forward to treating more patients in the upcoming PARADIGME study.”

The new Phase l/ll study data is expected to help Nordic to conduct the Phase llb PARADIGME trial for relapsed/refractory (R/R) indolent NHL (iNHL) and FL diseases.

Currently, Nordic Nanovector is engaged in the development of new therapies to address major unmet medical needs and advance cancer care.