Periprosthetic joint infection is the most prevalent complication of joint replacement surgery. Credit: Esther Max / Flickr (Creative Commons).

Peptilogics has dosed the first subject in the Phase Ib LOGIC-1 clinical trial of investigational product PLG0206 to treat periprosthetic joint infections (PJI) occurring following a total knee arthroplasty (TKA). 

The open-label, dose-escalating trial will enrol subjects who are undergoing a debridement, antibiotics, and implant retention (DAIR) surgical procedure to treat PJI following TKA. 

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It will analyse the safety and effects of PLG0206 for treating PJI.

The trial subjects will be followed up for nearly one year following treatment.

A non-traditional, broad-spectrum antibiotic peptide therapy, PLG0206 can act on bacteria and persistent pathogens that form a biofilm and evade traditional antibiotics. 

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PLG0206 showed robust activity against Gram-positive and Gram-negative antibiotic-resistant bacteria with a reduced resistance development risk to the therapeutic in in vitro and non-clinical studies. 

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The therapy has received Orphan Drug and Fast Track designation from the Food and Drug Administration to treat PJI.

Peptilogics founder and CEO Jonathan Steckbeck said: “As we continue to reimagine the future of peptide therapeutic discovery, it is incredibly promising to have reached this milestone with our first programme. 

“PLG0206 has demonstrated potential best-in-class, rapidly bactericidal, broad-spectrum activity against a variety of biofilm pathogens in both in vitro and non-clinical studies, and safety in a previously completed Phase I study in healthy volunteers.” 

PJI is the most prevalent complication of joint replacement surgery, with patients needing an average of three surgeries for treatment, if diagnosed with PJI. 

With a recurrence rate of up to 60% and a five-year death rate of 25%, the infection currently has no effective treatment.