Elarekibep is used for the treatment of moderate-to-severe asthma. Credit: Yale Rosen / commons.wikimedia.org.

Pieris Pharmaceuticals has completed the safety review of the 10mg dry powder dose safety cohort from the Phase IIa trial of inhaler-formulated elarekibep (PRS-060/AZD1402) for the treatment of moderate-to-severe asthma.

An IL-4 receptor alpha inhibitor elarekibep is currently under development in partnership with AstraZeneca.

Go deeper with GlobalData

Data Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

The ongoing multi-centre, placebo-controlled study has examined the pharmacokinetics and safety profile of the dry powder formulation in 13 asthma patients who received elarekibep twice daily over four weeks along with medium dose inhaled corticosteroids with long-acting beta agonists.

AstraZeneca evaluated the changes in laboratory markers, incidence of adverse events and forced expiratory volume in one second against a placebo.

Topline data from the trial is expected by the middle of next year.

See Also:

Pieris will also have a co-development option for this programme with AstraZeneca, upon completion of the Phase IIa study.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Pieris president and CEO Stephen Yoder said: “We look forward to the completion of the Phase IIa study which, if successful, would serve as a key value inflection point in the development of this underserved, large market opportunity and will inform our decision to co-develop elarekibep alongside AstraZeneca.”

The safety review of the 10mg dose will further enable the company to evaluate elarekibep at doses of 10mg or less in its future trials.

Elarekibep is Pieris’ lead respiratory Anticalin-based drug candidate which is to be inhaled directly into the lungs.