Receive our newsletter – data, insights and analysis delivered to you
  1. News
June 12, 2020

Regeneron starts trial of Covid-19 antibody cocktail

Regeneron Pharmaceuticals has commenced the first clinical trial of its dual antibody cocktail, REGN-COV2, which is intended to prevent and treat Covid-19.

Regeneron Pharmaceuticals has commenced the first clinical trial of its dual antibody cocktail, REGN-COV2, which is intended to prevent and treat Covid-19.

The REGN-COV2 clinical programme will involve hospitalised patients, non-hospitalised symptomatic patients, uninfected individuals in groups at high exposure risk, such as healthcare works, and uninfected people with close exposure to a Covid-19 patient.

Regeneron noted that the placebo-controlled trials will be performed at several sites.

The company analysed numerous fully-human antibodies generated using the company’s VelocImmune mice, along with antibodies isolated from recovered Covid-19 patients.

Based on the findings, the company chose the two most potent virus-neutralising antibodies and scaled them up for clinical use by using its in-house VelociMab and manufacturing capabilities.

According to preclinical research, the selected dual antibodies attach non-competitively to the receptor binding domain (RBD) of the virus’ spike protein.

Content from our partners
The importance of reference products in biosimilar trials, and how to source them
Africa’s last mile: Building viable vaccine supply chains
Why this global life sciences COO believes relocation to Charleston, SC, was key to achieving next-level success

The first two adaptive Phase I/II/III trials, REGN10933 and REGN10987, are designed to assess REGN-COV2 for the treatment of hospitalised and non-hospitalised Covid-19 patients.

The Phase I part of the trials will track virologic and safety endpoints, while the Phase II part will focus on virologic and clinical endpoints. The Phase I and Phase II results will help refine the endpoints and determine the size for the Phase III studies.

Regeneron Pharmaceuticals co-founder, president and chief scientific officer George Yancopoulos said: “We have created a unique anti-viral antibody cocktail with the potential both to prevent and treat infection, and also to preempt viral ‘escape,’ a critical precaution in the midst of an ongoing global pandemic.

“REGN-COV2 could have a major impact on public health by slowing spread of the virus and providing a needed treatment for those already sick, and could be available much sooner than a vaccine.”

The antibody cocktail is also expected to show long-term utility for elderly and immuno-compromised patients.

In March this year, Regeneron and Sanofi initiated a clinical programme of rheumatoid arthritis drug Kevzara (sarilumab) to treat hospitalised patients with severe Covid-19.

Related Companies

Topics in this article:
NEWSLETTER Sign up Tick the boxes of the newsletters you would like to receive. Key drug pipeline and competitive landscape changes based on the latest clinical activity, sent every Tuesday. Curated analysis and data-driven insights on clinical trials strategy and operations, sent every Thursday. The pharmaceutical industry's most comprehensive news and information delivered every month.
I consent to GlobalData UK Limited collecting my details provided via this form in accordance with the Privacy Policy