The prospective trial will analyse SRSD107 to treat and prevent thromboembolic ailments. Credit: Kateryna Kon / Shutterstock.com.

Sirius Therapeutics has filed an application in Australia to commence a first-in-human clinical trial of a long-acting next-generation anticoagulant, SRSD107, to treat and prevent thromboembolic ailments. 

A double-stranded small interfering ribonucleic acid (siRNA) therapy, SRSD107 acts on coagulation factor XI (FXI) and blocks the expression of FXI protein.

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This approach hinders the coagulation pathway and boosts anticoagulant/anti-thrombotic effects.

The potential anticoagulant therapeutic is the first compound of the company to enter the clinic across the globe.

Sirius Therapeutics CEO Dr Qunsheng Ji said: “We have made rapid progress in developing SRSD107 and other candidates in our pipeline since Sirius was established two years ago. 

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“The exceptional durability of pharmacology and safety profile suggests SRSD107 has the potential to be a best and first-in-class FXI siRNA therapeutic. 

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“We aspire to develop SRSD107 as a transformative medicine with a dosing schedule of once semi-annually or potentially annually for patients who need chronic anticoagulants.”

According to data from preclinical in-vivo research, a single subcutaneous dose of SRSD107 offered a nearly 100% decline in FXI levels for up to six months without any bleeding events.

Last month, the company secured $60m in a Series B funding round led by Hankang Capital.

The company intends to utilise the investment capital to progress the clinical development of its siRNA therapeutics and develop next-generation RNA delivery technologies. 

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