SiteOne Therapeutics has initiated dosing in Phase I study of its experimental intravenous, non-opioid analgesic, ST-2427, for managing moderate to severe pain.

ST-2427 is a highly selective inhibitor of sodium ion channel 1.7 (NaV1.7) that is highly expressed in peripheral nerve fibres. It is established as a target for pain treatment by human genetics.

People who lack this protein cannot experience pain, so by selectively targeting NaV1.7, ST-2427 can potentially prevent the electrical signals responsible for pain from reaching the central nervous system (CNS).

The randomised, double-blind, placebo-controlled, dose-escalation study will assess the safety, tolerability, and pharmacokinetics of ST-2427 in healthy adults.

The trial is currently enrolling participants at AltaSciences in Overland Park, Kansas, US. They will be randomly given a single dose of ST-2427 or placebo.

It will evaluate the effects of the treatment on vital signs, such as cardiac and respiratory function and body temperature over varying doses of ST-2427.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

The safety, tolerability and pharmacokinetics data will be used to detect the doses and study design for Phase II studies in individuals with acute pain.

SiteOne Therapeutics CEO John Mulcahy said: “There is an urgent, unmet need to develop effective non-opioid therapies for pain.

“Our lead compound, ST-2427, addresses that need by targeting the peripheral nerve fibres that conduct pain signals without the potential for CNS side effects, addiction and abuse liability of opioid medications.”

The company recently announced plans to expand its technology platform and clinical development works to include hypersensitivity disorders more broadly in both the peripheral and central nervous systems. Such disorders include chronic cough, neuropathic pain, ocular discomfort, and pruritus.

SiteOne Therapeutics chief development officer Debra Odink said: “SiteOne has discovered exquisitely selective modulators of multiple sodium channel subtypes, and we are now advancing development candidates for a number of indications, starting off by addressing acute pain.”