Inflammatory bowel diseases (IBD), which include Crohn’s disease and ulcerative colitis, are estimated to affect around 2 million US adults. Image credit: Shutterstock/meeboonstudio

Telavant has kickstarted its trial investigating its treatment candidate RVT-3101 for Crohn’s disease (CD), completing the first patient dosing.

The TAHOE study (NCT05910528) is a global, randomised, double-blind study in a predicted 105 participants with moderate to severely active CD. Telavant, part of Roivant, is evaluating two doses of RVT-3101 administered once a month, with patient assessment at week 14. The primary endpoint is the proportion of participants achieving clinical remission per Crohn’s Disease Activity Index (CDAI). The secondary outcome is the proportion of participants achieving an endoscopic response.

Go deeper with GlobalData

Premium Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

RVT-3101 is a drug being investigated for other bowel disease indications. In June, Roivant announced positive results from a Phase 2b study (TUSCANY-2) indicating improved clinical remission in ulcerative colitis.

The Wall Street Journal recently reported that Roivant is in talks to sell the drug to Roche for a potential $7bn deal.

“Despite the availability of multiple treatment options, many Crohn’s disease patients do not achieve adequate disease control,” said Professor Geert D’Haens, gastroenterologist and investigator at Amsterdam UMC.

See Also:

“TL1A provides a compelling therapeutic target to treat inflammatory bowel diseases (IBD) and the IBD community is excited about the potential for RVT-3101 as a new treatment approach for UC and CD patients.”

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Inflammatory bowel diseases (IBD), which include CD and ulcerative colitis, are estimated to affect around 2 million US adults. Telavant says that even the most advanced therapies typically lead to a 10-15% disease remission, meaning flare-ups and continued symptoms are still an issue. It adds that no approved medication directly addresses the fibrotic component of IBS. 

“We are excited to broaden the potential of RVT-3101 with the initiation of the TAHOE Phase 2 study as we believe its novel mechanism of action, addressing both inflammation and fibrosis, can make a significant impact on patients suffering with Crohn’s disease,” said Bittoo Kanwar, chief medical officer of Telavant.