Researchers at Baylor College of Medicine, George Washington University in the US and the René Rachou Institute in Brazil have obtained National Institutes of Health (NIH) funding to conduct the Phase Ib clinical trial of a vaccine to treat schistosomiasis, a deadly parasitic infection.

A consortium of partners developed the vaccine under a product development alliance led by Center for Vaccine Development at Texas Children’s Hospital.

The double-blind, randomised and controlled Phase Ib trial will test two formulations of the vaccine in up to 60 healthy males and non-pregnant females to protect against the intestinal/liver schistosomiasis caused by schistosoma mansoni.

Baylor College of Medicine infectious diseases professor Dr Robert Atmar said: “The main purpose of the study is to assess the vaccine safety in a group of healthy adults who may have previously been exposed to schistosomiasis.

“People are treated for schistosomiasis only to be rapidly reinfected, creating a vaccine is critical to stopping this cycle.”

“The investigative team will also evaluate the ability of different doses of the vaccine with or without adjuvant to induce antibody and cellular immune responses to the vaccine agent.”

The researchers have conducted the previous Phase I trial of the vaccine in 2015 at Baylor College of Medicine, and plan to perform the latest study in Americaninhas, Brazil.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Patients for the trial will be enrolled by investigators from the George Washington University at a clinical site developed in collaboration with the René Rachou Institute.

George Washington University School of Medicine and Health Sciences microbiology, immunology and tropical medicine associate professor Dr David Diemert said: “Right now, people are treated for schistosomiasis only to be rapidly reinfected. Creating a vaccine is critical to stopping this cycle.”