ValiSeek reports positive Phase II data of VAL401 to treat cancer

17th January 2018 (Last Updated January 17th, 2018 00:00)

ValiRx and Tangent Reprofiling joint venture (JV) ValiSeek has reported positive data from a Phase II clinical trial of VAL401 for the treatment of late-stage non-small cell lung cancer. 

ValiRx and Tangent Reprofiling joint venture (JV) ValiSeek has reported positive data from a Phase II clinical trial of VAL401 for the treatment of late-stage non-small cell lung cancer.

Evaluated by digital health company Ariana, the data demonstrated that VAL401 treatment has significantly improved patients' quality of life and had a positive impact on the disease.

While analysing the study results, Ariana used its Knowledge Extraction and Management (KEM) advanced artificial intelligence technology to identify positive relations between response and pharmacokinetic parameters and between response and pre-treatment with particular chemotherapies.

This could lead to the potential for combining VAL401 with these particular chemotherapies.

"This data advocates the potential for VAL401 in treating very late-stage cancer patients in the palliative arena."

The rate of progression-free survival (PFS), blood biochemistry, quality of life data obtained from the study were also assessed by Ariana.

ValiSeek CEO Dr Suzy Dilly said: “This data advocates the potential for VAL401 in treating very late-stage cancer patients in the palliative arena.

“It also advocates the potential for VAL401, in the as yet untested combinations with, both traditional chemotherapies and immune-oncology treatments.

“Palliative stage patients could expect to see improvements in symptoms with the added benefit of improved survival prospects. This encouraging 60% overall response rate seen in this first all-comer trial provides a strong foundation for the next stage of clinical testing.”

According to Dilly, the measure of immune competency of the treated patients of the trial was also found to be highly effective.