Nodular glomerulosclerosis

Research-based biopharmaceutical company AbbVie has started Phase 3 in study of investigational compound atrasentan on renal outcomes in patients with diabetic nephropathy.

The ‘Study Of Diabetic Nephropathy with Atrasentan’ (SONAR) is designed to assess the effects of atrasentan upon addition to standard of care on progression of kidney disease in patients with stage 2 to 4 chronic kidney disease (CKD) and type 2 diabetes.

The SONAR steering committee co-chair chair Dick de Zeeuw said there was an urgent need to find new medications for nephropathy in patients with type 2 diabetes with high risk to end up in dialysis.

"Phase 2 studies of atrasentan in this patient population have shown encouraging results, and we look forward to further evaluating this investigational treatment in the Phase 3 SONAR study," de Zeeuw said.

The multinational, double-blind, placebo-controlled study will enrol more than 4,000 patients with diabetic nephropathy.

The atrasentan’s impact on renal outcomes, including the onset of end-stage renal disease (ESRD), as defined by need for chronic dialysis, transplant or death due to renal failure progression, will be assessed.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

AbbVie dyslipidemia and renal divisional vice president James Stolzenbach said: "If validated in Phase 3, atrasentan has the potential to provide a novel treatment option for type 2 diabetic kidney disease patients worldwide."

Image: Nodular glomerulosclerosis in the kidney of a patient with diabetic nephropathy. Photo: courtesy of CDC.