Ablynx has collaborated with Merck, known as MSD outside the US and Canada, to develop therapeutic nanobody candidates against a voltage-gated ion channel, with the option to elect a second target.

According to the agreement, Merck has exclusive global rights to nanobodies against the chosen target, with an opportunity for similar rights for a second target, while Ablynx will earn a €6.5m upfront payment and €2m in research funding.

Go deeper with GlobalData

Premium Insights

The gold standard of business intelligence.

Find out more

Ablynx will be responsible for discovering nanobody candidates, while Merck will be responsible for their research, development, manufacturing and commercialisation.

Ablynx chairman and CEO Dr Edwin Moses said the collaboration is in the area of ion channels, where to date monoclonal antibodies have demonstrated little success.

"Due to the formatting flexibility of nanobodies, we are able to combine antibody-like selectivity and multi-specificity in one molecule, making them ideal candidates for ion channel modulators," Dr Moses said.

See Also:

"Ablynx will be responsible for discovering nanobody candidates, while Merck will be responsible for their research, development, manufacturing and commercialisation."

"This agreement reflects the potential power of the nanobody platform and the considerable success we have had to date with seven nanobody programmes at the clinical development stage."

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Ablynx is also eligible to earn up to €448m in research, regulatory and commercial milestone payments upon the advancement of multiple candidates, and will receive tiered royalties from any products derived from the collaboration.

Merck neuroscience discovery research head and vice president Dr Richard Hargreaves said; "We are excited to be working with Ablynx to evaluate the potential of the Nanobody technology directed towards this challenging ion channel target."