Clinical-stage biotechnology company Alios BioPharma has commenced patient dosing with nucleoside analog ALS-8176 in a Phase I trial to treat respiratory syncytial virus (RSV) infection.
A structurally novel, anti-respiratory syncytial virus (RSV) nucleoside analog, ALS-8176 is the only known analog that is currently being developed for the treatment of acute RSV infection.
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Preclinical studies demonstrated the potent anti-viral activity of the investigational compound across multiple strains of RSV by targeting the RSV polymerase.
Alios BioPharma chief executive officer Dr Lawrence Blatt said ALS-8176 has the potential to become an effective first-line antiviral therapy for RSV infection, for which only few treatments are currently available.
"The advancement of ALS-8176 for RSV, together with the recently reported positive clinical data with VX-135 (formerly ALS-2200, an anti-HCV nucleotide analog), demonstrates the broad capabilities of the Alios discovery platform," Blatt said.
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"We are currently utilising this platform to screen against several infectious diseases with high unmet medical needs."
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By GlobalDataDesigned to assess the safety, tolerability and pharmacokinetics of single ascending doses and multiple ascending doses of orally administered ALS-8176, the randomised, double-blind study will include around 90 healthy adult volunteers.
Image: Transmission electron micrograph of respiratory syncytial birus. Photo: Courtesy of MarcoTolo.
