Biopharmaceutical company Dyax has dosed the first subject in a Phase I study of fully human monoclonal antibody inhibitor of plasma kallikrein, DX-2930, leveraging the company’s phage display technology platform.

The study will assess the safety and tolerability of single administration of DX-2930, developed by the company as a subcutaneous injection for the prevention of hereditary angioedema (HAE) attacks.

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Dyax executive vice president and chief medical officer Dr Burt Adelman said that there is a significant requirement for an effective, safe and well tolerated prophylactic agent to treat HAE.

"DX-2930 is a highly potent, long-acting, fully human monoclonal antibody that binds specifically to active plasma kallikrein."

"DX-2930 is a highly potent, long-acting, fully human monoclonal antibody that binds specifically to active plasma kallikrein," Adelman added.

"We look forward to completing this study and moving forward rapidly with this important clinical program."

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The single-centre, randomised, double-blind, placebo-controlled study will assess the safety and tolerability of DX-2930 as well as characterise the pharmacokinetics (PK) of single, subcutaneous administrations of the investigational candidate in healthy subjects.

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The study conducted at the clinical trials unit of Vince & Associates Clinical Research will enrol approximately 32 subjects into four ascending dose cohorts (n=8 per cohort) of DX-2930 or placebo.

Dyax president and CEO Gustav Christensen said, "We believe our knowledge of the plasma kallikrein pathway provides us with unique insight and a significant advantage in developing and commercialising this product candidate."