Genentech has announced data from the ADACTA study comparing the reduction in signs and symptoms during monotherapy treatment with Actemra (tocilizumab) versus Adalimumab in adult rheumatoid arthritis (RA) patients who have either intolerance to MTX or for whom continued MTX treatment is inappropriate.

The RA patients who received Actemra as single-agent therapy in the Phase 4 multicentre, randomised, double-blinded, parallel group study, experienced a significantly greater improvement in disease activity after 24 weeks, compared to patients who received Adalimumab as single-agent therapy.

Genentech global product development head and chief medical officer, Hal Barron, said that since there are a number of therapies approved for patients with RA, it is important for them and their healthcare provider to have the information they need to choose the best individual treatment option.

"This study showed that for patients requiring biologic monotherapy, Actemra was more effective than Adalimumab, meaning that patients were more likely to experience DAS28 remission, greater improvement in joint pain and swelling, and an improved quality of life," Barron added.

The study demonstrated that after 24 weeks of treatment, adult RA patients achieved a mean improvement in disease activity (DAS28 score reduction) of 3.3 with Actemra, compared to 1.8 with Adalimumab.

A DAS28 remission rate of 40% with Actemra versus 11% with Adalimumab was observed.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Adverse event profiles were comparable in the two treatment groups and the safety data of Actemra in the study was consistent with the previous trials.

Changes in laboratory values such as transaminase elevations, neutrophil reductions and LDL elevations occurred in both arms, with the proportion of patients with abnormal values higher in the Actemra arm.

Image: Building 32, one of the buildings on Genentech’s headquarters campus, in South San Francisco. Photo courtesy of: Coolcaesar.