Biopharmaceutical company GTx is commencing a Phase II open-label study of selective androgen receptor modulator enobosarm (GTx-024), to treat estrogen receptor (ER) positive metastatic breast cancer.
The proof-of-concept study is designed to randomise 20 postmenopausal women with ER-positive metastatic breast cancer, and who have previously responded to hormone therapy, at around six sites in the US.
Go deeper with GlobalData
Dana Farber Cancer Institute inflammatory breast cancer programme director, Harvard Medical School assistant professor of medicine and enobosarm Phase II study clinical investigator Dr Beth Overmoyer said androgen (male hormone) therapy can be effective for women who’s cancer has progressed after tamoxifen treatment, but side-effects such as deepening of the voice and facial hair growth make this option unacceptable to many.
"Hopefully, treatment with enobosarm will result in efficacy similar to androgen therapy without the masculinising side effects," Overmoyer said.
Until the women show clinical progression or have completed the 336-day treatment period, 9mg of enobosarm will given each day.
See Also:
Clinical benefit, which will be assessed at six months, is the primary endpoint, and is defined as either those women receiving treatment who have demonstrated a complete response, a partial response or stable disease.
How well do you really know your competitors?
Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.
Thank you!
Your download email will arrive shortly
Not ready to buy yet? Download a free sample
We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form
By GlobalDataGTx chief executive officer Mitchell Steiner said; "Enobosarm would be the first new targeted hormonal therapy introduced for the treatment of breast cancer in many years."
