Receive our newsletter – data, insights and analysis delivered to you
  1. Uncategorized
  2. c-icon icon-chevron-right
August 15, 2013

Ligand signs deal with CURx to develop Captisol-enabled topiramate injection

Ligand Pharmaceuticals has signed a licensing deal with CURx Pharmaceuticals to develop and commercialise its Captisol-enabled topiramate injection to treat partial onset or primary generalized tonic-clonic seizures in hospitalised epilepsy patients.

Ligand Pharmaceuticals has signed a licensing deal with CURx Pharmaceuticals to develop and commercialise its Captisol-enabled topiramate injection to treat partial onset or primary generalised tonic-clonic seizures in hospitalised epilepsy patients.

Under the deal, Ligand is eligible for more than $21m in potential net milestone payments and net royalties on future sales of 6% to 7.5%.

Ligand president and chief executive officer John Higgins said the deal pairs its proven formulation agent with an approved medicine to create a potentially novel, and differentiated drug.

"We are very pleased to be entering this agreement. CURx is highly motivated to advance development with current plans calling for a Phase II trial to commence in 2014," Higgins added.

The Captisol-enabled formulation of Topiramate Injection was designed for the treatment of partial onset or primary generalised tonic-clonic seizures in hospitalised epilepsy patients who are unable to take oral topiramate.

Initially developed at, and exclusively licensed from, the University of Minnesota, the Captisol-enabled formulation of Topiramate Injection provides an intravenous or intramuscular option for hospitalised epilepsy patients unable to use oral topiramate, and has been studied in Phase I trials.

Content from our partners
Africa’s last mile: Building viable vaccine supply chains
Why this global life sciences COO believes relocation to Charleston, SC, was key to achieving next-level success
Patient-centric pharma logistics: How CRYOPDP delivers hope worldwide

Janssen Pharmaceuticals sold Topiramate under the trade name Topamax and is presently available in oral formulations.

CURx chief executive officer and founder Dinu Sen said, "In Phase I trials in healthy volunteers and patients at the University of Minnesota, the product demonstrated a faster onset of action than the orally administered drug."

Invented and initially developed at the University of Kansas’ Higuchi Biosciences Center for specific use in drug development and formulation, Captisol is a chemically modified cyclodextrin with a structure designed to optimise the solubility and stability of drugs.

Related Companies

NEWSLETTER Sign up Tick the boxes of the newsletters you would like to receive. Key drug pipeline and competitive landscape changes based on the latest clinical activity, sent every Tuesday. Curated analysis and data-driven insights on clinical trials strategy and operations, sent every Thursday. The pharmaceutical industry's most comprehensive news and information delivered every month.
I consent to GlobalData UK Limited collecting my details provided via this form in accordance with the Privacy Policy
SUBSCRIBED

THANK YOU