PsychoGenics, a preclinical contract research organisation, has announced positive results from the study evaluating eltoprazine in levodopa induced dyskinesia (LID) in Parkinson’s disease (PD) patients.

Eltoprazine, a selective 5-HT1A/1B partial agonist, met the primary objective of the study and was well tolerated with no serious adverse events reported.

PsychoGenics president and CEO, Emer Leahy, said the results of this trial are compelling and show that eltoprazine has the potential to address a critical unmet need in Parkinson’s disease.

"The Michael J Fox Foundation for Parkinson’s Research partially supported the trial."

"With these promising positive data we now intend to progress eltoprazine to market as quickly as possible with support from a partner," Leahy added.

Eltoprazine exhibited a statistically significant reduction in LID at the 5mg dose (p = 0.0007) and the 7.5mg dose (p = 0.0467), without adversely affecting levodopa efficacy, thereby achieving the primary objective.

The double-blind, placebo-controlled, dose-finding study, conducted at two sites in Sweden, randomised twenty-two patients.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

The subjects were dosed with eltoprazine and placebo, along with a challenge dose of levodopa at each of the five treatment visits.

The study assessed parkinsonian and dyskinesia symptoms over a period of three hours post-treatment and the assessments were video-taped and scored by two independent blinded raters.

The Clinical Dyskinesia Rating Scale (CDRS) and the Unified Parkinson’s Disease Rating Scale (UPDRS) were used to measure the primary efficacy.

Secondary endpoints comprised the Rush Dyskinesia Rating Scale and evaluation of the patients’ mood using the Hospital Anxiety and Depression Score (HADS) and Montgomery-Asberg Depression Rating Scale (MADRS).

The Michael J Fox Foundation for Parkinson’s Research partially supported the trial with a grant.

The Michael J Fox Foundation CEO, Todd Sherer, said: "The results presented by PsychoGenics and Dr Bjorklund show early promise in finding a potential treatment for dyskinesia and we look forward to working with this team to drive their program forward."