TG Therapeutics and Rhizen Pharmaceuticals have partnered to develop and commercialise Rhizen’s PI3K delta inhibitor, TGR-1202, previously known as RP5264.

Under the collaboration, which will initially focus on hematologic malignancies and autoimmune disease indications, the companies will jointly develop the product on a worldwide basis, excluding India.

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Rhizen will contribute backup molecules, enabling TG to develop differentiated therapies against hematologic cancers and autoimmune diseases.

TG Therapeutics executive chairman and interim CEO Michael S Weiss said the company has entered into collaboration with Rhizen due to their innovative pre-clinical development program, which has yielded an impressive portfolio of PI3K delta inhibitors.

"TGR-1202 has already demonstrated encouraging pre-clinical activity, and will serve to expand our pipeline as we seek to develop much needed therapies for patients suffering from hematologic malignancies," Weiss said.

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Under the agreement, TG will cover the costs of clinical development up to Phase II, after which the companies will be jointly responsible.

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Rhizen is eligible to receive upfront, development, and commercialisation milestone payments in addition to royalties tied to net sales, the aggregate of which is expected to exceed $250m.

Rhizen president Swaroop Vakkalanka said; "The deep clinical and regulatory development knowledge and experience of the team at TG Therapeutics, and the existing clinical program focused on B-cell malignancies, makes TG an ideal partner with which to collaborate on development of TGR-1202."

Rhizen will maintain rights to manufacture and supply the product to TG Therapeutics, which will be responsible for all clinical and regulatory development for TGR-1202.