Arena Pharmaceuticals’ Phase IIb olorinab for abdominal pain due to irritable bowel syndrome (IBS) saw a five-point drop in its FDA likelihood of approval (LoA) as of 4 March. The LoA decrease is due to the Phase IIb CAPTIVATE trial not meeting its primary efficacy endpoint of average abnormal pain score (AAPS) improvements versus placebo measured in a 12-week timeframe, as revealed in a 2 March media release.

Olorinab already had a low LoA of 7%, which dropped further to 2% due to CAPTIVATE data, according to GlobalData analysis using a combination of machine learning and its proprietary algorithm. While the 273-patient CAPTIVATE did not succeed in its primary endpoint, subgroup analysis shows 50mg olorinab may offer relief in patients with moderate-to-severe pain, with the company indicating it expects to evaluate possible strategic options for the asset, as per the media release.

On 26 March 2020, this news service reported olorinab’s positive Phase IIa data in Crohn’s disease may have limited bearing on CAPTIVATE’s potential for trial success. The 14-patient Crohn’s disease trial is too small to gauge the drug’s overall efficacy prospects, experts said, and the two indications have different etiologies and possibly sources of pain. Olorinab targets cannabinoid receptor type 2 (CB2). Arena has a market cap of $4.49bn.

Reynald Castaneda is an Associate Editor for Clinical Trials Arena parent company GlobalData’s investigative journalism team. A version of this article originally appeared on the Insights module of GlobalData’s Pharmaceutical Intelligence Center. To access more articles like this, visit GlobalData.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.