Juno Therapeutics clinical trial put on hold after 2 patients died – CNBC News
CNBC News reports the FDA intervened and placed a phase 2 clinical on hold last week after two patients died. The drug, being developed by Juno Therapeutics, was being used to treat patients with leukaemia.
“The company said that the deaths occurred after it added fludarabine, a chemotherapy drug, to its pre-conditioning regimen. Juno suggested to the FDA that clinical trials continue using cyclophosphamide pre-conditioning on its own.”
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Ampio Pharmaceuticals fails second Phase 3 Osteoarthritis Trial – AO Markets
AO Markets reported last week that shares of Ampio Pharmaceuticals stock fell by 61 percent after the company revealed a phase 3 clinical trial treating patients with osteoarthritis had failed.
The company’s drug, Ampion, was being tested “in a 480 patient trial in patients with osteoarthritis of the knee.” It is believed the drug failed to meet the clinical trial’s primary endpoint.
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Salmonella 'game-changer' could shrink cancer cells – BBC News
According to the BBC, researchers at Swansea University revealed they may have made a breakthrough that could transform treatment for prostate cancer.
By using a strain of salmonella bacteria, scientists at Swansea University’s School of Medicine have found a way to shrink cancer cells, isolating the tumour while leaving healthy tissues unaffected.
Experts say this novel treatment could be a ‘game changer’ in oncology.
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New NIH-Funded Center to Study Inefficiencies in Clinical Trials – Duke Today
Last week Duke Today revealed researchers from Vanderbilt University Medical Center and Duke Clinical Research Institute received a federal grant to learn how multisite clinical trials can be carried more rapidly and efficiently.
The $26.5 million grant has received the backing of the National Center for Advancing Translational Sciences of the National Institutes of Health (NIH). It is believed the funds are essential in establishing the joint Trial Innovation Network, which is the newest part of the Clinical and Translational Science Award Program.
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Many Clinical Trials Not Listed at Clinical Study Data Request Website – Endochronology Advisor
According to a research letter published in the Journal of the American Medical Association, roughly 50 percent of studies listed on ClinicalTrials.gov are registered in its data-sharing repository.
Experts from Paris Descartes University in France studied “the proportion of randomized clinical trials (RCTs) registered at ClinicalTrials.gov that was listed on the Clinical Study Data Request (CSDR) data-sharing repository website.
“The researchers found that there were 966 RCTs (462,751 participants) for the 61 targeted drugs from the 4 sponsors; 53 percent of these trials (with 74 percent of participants) were listed at CSDR.”
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PHOTO CREDIT: Jon S via Flickr Creative Commons