Receive our newsletter – data, insights and analysis delivered to you
  1. News
November 30, 2021

AB Science begins dosing in Phase II Covid-19 trial

The Phase II clinical trial will evaluate masitinib’s antiviral efficacy by administering it at three different dosages.

AB Science has dosed the first subject in its Phase II trial, which will assess the antiviral activity of masitinib in Covid-19 patients.

The latest move comes after the company received approval from the South African and Russian Regulatory Authorities to begin the study, in September.

An orally administered tyrosine kinase inhibitor, masitinib targets mast cells and macrophages, mainly cells for immunity.

The double-blind, randomised, placebo-controlled Phase II clinical trial will assess the efficacy of masitinib in symptomatic mild to moderate patients diagnosed with Covid-19.

It will evaluate the therapy’s antiviral efficacy by administering it at three different dosages.

The clinical study will enrol 78 non-hospitalised patients with mild disease or those hospitalised with Covid-19 without the need for non-invasive ventilation.

Content from our partners
Africa’s last mile: Building viable vaccine supply chains
Why this global life sciences COO believes relocation to Charleston, SC, was key to achieving next-level success
Patient-centric pharma logistics: How CRYOPDP delivers hope worldwide

AB Science co-founder and CEO Alain Moussy said: “The new Omicron variant reminds us that the SARS-CoV-2 virus is rapidly evolving with the selection and accumulation of mutations, mainly in the Spike protein, and that these mutations may lead to increased transmissibility of the virus and potential evasion of some vaccines.

“Evidently, there is a continued need for effective antiviral treatments that are insensitive to these variants.”

The trial’s primary efficacy goal will be to demonstrate that the therapy can reduce the SARS-CoV-2 viral load faster compared to a placebo control group, which will be given best supportive care (BSC).

Moussy added: “We are committed to continuing the clinical development of masitinib in Covid-19 because this pandemic is clearly not over yet.

“Moreover, masitinib appears to be a unique drug in the anti-Covid arsenal, having potential therapeutic activity across all of its stages by merit of its dual antiviral/anti-inflammatory mechanism of action.”

Related Companies

Topics in this article:
NEWSLETTER Sign up Tick the boxes of the newsletters you would like to receive. Key drug pipeline and competitive landscape changes based on the latest clinical activity, sent every Tuesday. Curated analysis and data-driven insights on clinical trials strategy and operations, sent every Thursday. The pharmaceutical industry's most comprehensive news and information delivered every month.
I consent to GlobalData UK Limited collecting my details provided via this form in accordance with the Privacy Policy
SUBSCRIBED

THANK YOU