eFFECTOR Therapeutics has reported positive interim data updates from a Phase II expansion cohort of zotatifin along with fulvestrant and abemaciclib (ZFA triplet) for the treatment of ER+ metastatic breast cancer (mBC).

The expansion cohort enrolled 20 patients who received the ZFA triplet with zotatifin 0.07mg/kg on days 1 and 8 of 21-day cycles.

Out of 19 patients, five RECIST-evaluable patients achieved a partial response including four confirmed and one unconfirmed.

The ZFA triplet was found to be well tolerated and three patients discontinued due to adverse events of any cause. The majority of AEs were Grade 1 or 2.

eFFECTOR Therapeutics president and CEO Steve Worland said: “The activity observed with the ZFA triplet, with partial responses seen in 26% of patients, is substantially higher than we would expect for treating such heavily pretreated patients with just fulvestrant and abemaciclib.

“We believe this activity level reflects in part zotatifin’s mechanism of down-regulating cyclins D and E, and the synergy this provides with CDK4/6 inhibition.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

“The partial response observed at a higher dose of zotatifin in combination with only fulvestrant is encouraging and we look forward to reporting data from the completed dose escalation in the second half of 2023.”

Partial response was also observed in one of three patients who received zotatifin 0.1mg/kg and fulvestrant (ZF doublet).