View all newsletters
Receive our newsletter – data, insights and analysis delivered to you
  1. News
July 22, 2021

Sorrento doses subjects in Covid-19 trial of intranasal drug in the UK 

The efficacy trial will enrol nearly 350 Covid-19 patients who have mild symptoms or are asymptomatic.

Sorrento Therapeutics has dosed subjects in Phase II trial of its intranasal drug, COVIDROPS, for the treatment of Covid-19 in the outpatient setting in the UK.

Free Whitepaper
img

Unlocking the clinical trial potential of Africa

Ongoing improvements around infrastructure, continued investment, and being home to one of the world’s largest working age populations, means that Africa’s role in the clinical trials market has transformed. In this whitepaper, Oximio outlines the dynamics of today’s clinical trial market in Africa, including the key challenges the region is facing and how sponsors can overcome them to unlock the continent’s growing potential.
by Oximio
Enter your details here to receive your free Whitepaper.

A neutralising antibody drug substance, COVIDROPS is meant for being instilled into both nostrils of people who are recently infected.

The large double-blind, randomised Phase II efficacy trial will enrol a total of nearly 350 Covid-19 patients with mild symptoms or without symptoms.

Subjects will receive 10mg or 20mg doses of COVIDROPS or placebo.

Sorrento noted that the trial utilises a new decentralised design in which participants are analysed and treated in the at-home setting.

The trial was launched on obtaining a quick review and approval from the UK Medicines and Healthcare products Regulatory Agency (MHRA).

In a safety trial carried out in the US, up to 60mg doses of COVIDROPS were found to have a safety profile in line with placebo in healthy participants.

Furthermore, the severity of all the adverse effects linked to the drug was observed to be mild.

The latest trial in the UK will complement Phase II trials being commenced in the US.

On obtaining positive safety and effectiveness data against Covid-19, Sorrento plans to seek emergency use authorisation in the US, the UK, Canada, India, Mexico and the EU, among other countries.

In animal and in vitro Covid-19 infection models, COVIDROPS was active against the original SARS-CoV-2 virus and the existing variants of concern (VoCs) in the US and the UK, including the Delta and Alpha variants.

The company is also developing another neutralising antibody to potentially act against all VoCs. Set to advance into the clinic, the second antibody is meant for intranasal and intravenous use.

Meanwhile, the Chinese National Medical Products Administration’s (NMPA) Center for Drug Evaluation (CDE) has approved Sorrento’s partner Escugen Biotechnology and its subsidiary Levena Biopharma’s application to begin a trial of TROP-2 ADC (ESG-401).

A recombinant humanised anti-trop2 Mab-SN38 conjugate, TROP-2 ADC (ESG-401) was co-developed by Escugen and Levena.

Related Companies

Free Whitepaper
img

Unlocking the clinical trial potential of Africa

Ongoing improvements around infrastructure, continued investment, and being home to one of the world’s largest working age populations, means that Africa’s role in the clinical trials market has transformed. In this whitepaper, Oximio outlines the dynamics of today’s clinical trial market in Africa, including the key challenges the region is facing and how sponsors can overcome them to unlock the continent’s growing potential.
by Oximio
Enter your details here to receive your free Whitepaper.

NEWSLETTER Sign up Tick the boxes of the newsletters you would like to receive. Key drug pipeline and competitive landscape changes based on the latest clinical activity, sent every Tuesday. Curated analysis and data-driven insights on clinical trials strategy and operations, sent every Thursday. The pharmaceutical industry's most comprehensive news and information delivered every month.
I consent to GlobalData UK Limited collecting my details provided via this form in accordance with the Privacy Policy
SUBSCRIBED

THANK YOU

Thank you for subscribing to Clinical Trials Arena