ProMIS Neurosciences has become the latest biotech to throw its hat in the ring of anti-amyloid antibodies targeting Alzheimer’s disease.

The Canadian pharma company will initiate a Phase Ia trial testing its monoclonal antibody PMN310 in healthy adults after gaining regulatory clearance with the US Food and Drug Administration (FDA). In later stages, ProMIS intends to test the drug in patients with Alzheimer’s disease.

ProMIS’s antibody follows a long line of anti-amyloid antibodies in the Alzheimer’s drug development space. PMN310 specifically targets toxic oligomers of amyloid-beta, which are thought to be a key driver of Alzheimer’s disease.

According to the long-held amyloid theory, stopping the accumulation of amyloid-beta plaque in the brain could slow Alzheimer’s progression. Amyloid plaque inhibition is the most common target in Alzheimer’s disease drug development, though some experts argue there could be better target pathways, according to GlobalData.

Anti-amyloid antibodies in Alzheimer’s disease

So far, two anti-amyloid antibodies have earned FDA accelerated approvals: Biogen’s Aduhelm (aducanumab) and Biogen’s and Eisai’s Leqembi (lecanemab). While Leqembi could become the market-leading Alzheimer’s therapy, Aduhelm has failed to gain market traction due to a series of high-profile controversies.

Meanwhile, the Alzheimer’s pipeline is full of late-stage anti-amyloid antibodies looking to join Leqembi and Aduhelm as FDA-approved therapies. Notably, Eli Lilly’s antibody donanemab reported positive Phase III results on May 3, setting the stage for a potential approval.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Nevertheless, it has not been all roses for anti-amyloid therapies. Last November, Roche announced that its antibody gantenerumab missed the primary endpoint in two Phase III trials. Some experts have also questioned whether amyloid is the optimal target in Alzheimer’s, arguing that the efficacy of anti-amyloid drugs has fallen short of stopping or reversing disease progression.