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Japan accounts for 4.7% share of global clinical trial activity in 2022

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China accounts for 27.7% share of global clinical trial activity in 2022

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US accounts for 18.4% share of global clinical trial activity in 2022

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Global clinical trials activity decreases 1.8% in Q4 2022 over 4Q average

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Global clinical trials activity decreases 8.8% YoY in Q4 2022

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Human Immunodeficiency Virus (HIV) Infections (AIDS) accounts for 6.3% share of global Infectious Disease clinical trial activity in 2021

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Type 2 Diabetes accounts for 35.5% share of global Metabolic Disorders clinical trial activity in 2021

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Type 1 Diabetes (Juvenile Diabetes) accounts for 7.3% share of global Metabolic Disorders clinical trial activity in 2021

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Pancreatic Cancer accounts for 5.8% share of global Oncology clinical trial activity in 2021

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Lung Cancer accounts for 16.3% share of global Oncology clinical trial activity in 2021

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Epilepsy accounts for 3.7% share of global Central Nervous System clinical trial activity in 2021

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Alzheimer’s Disease accounts for 2.8% share of global Central Nervous System clinical trial activity in 2021

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Global clinical trials activity decreases 12.2% in Q3 2022 over 4Q average

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Global clinical trials activity decreases 15.3% YoY in Q3 2022

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Schizophrenia accounts for 3.3% share of global Central Nervous System clinical trial activity in 2021

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Lupus Erythematosus accounts for 12.2% share of global Immunology clinical trial activity in 2021

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Depression accounts for 8.7% share of global Central Nervous System clinical trial activity in 2021

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Breast Cancer accounts for 11.3% share of global Oncology clinical trial activity in 2021

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Leukemia accounts for 9.6% share of global Oncology clinical trial activity in 2021

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Lymphoma accounts for 9.9% share of global Oncology clinical trial activity in 2021

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Prostate Cancer accounts for 4.3% share of global Oncology clinical trial activity in 2021

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Ovarian Cancer accounts for 4.6% share of global Oncology clinical trial activity in 2021

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Pain accounts for 45.8% share of global Central Nervous System clinical trial activity in 2021

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Psoriasis accounts for 17.2% share of global Immunology clinical trial activity in 2021

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Global clinical trials activity decreases 4.4% in Q2 2022 over 4Q average

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Global clinical trials activity decreases 7.6% YoY in Q2 2022

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Non-Alcoholic Steatohepatitis (NASH) accounts for 6.3% share of global Gastrointestinal clinical trial activity in 2021

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Stroke accounts for 15.1% share of global Cardiovascular clinical trial activity in 2021

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Rheumatoid Arthritis accounts for 20.8% share of global Immunology clinical trial activity in 2021

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Osteoarthritis accounts for 26.0% share of global Musculoskeletal Disorders clinical trial activity in 2021

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Hepatitis C accounts for 0.9% share of global Infectious Disease clinical trial activity in 2021

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Asthma accounts for 18.7% share of global Respiratory clinical trial activity in 2021

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Parkinson’s Disease accounts for 2.8% share of global Central Nervous System clinical trial activity in 2021

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Global clinical trials activity decreased 8.3% in Q1 2022 over 4Q average

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Global clinical trials activity decreased 9.4% YoY in Q1 2022

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Brazil accounts for 1.7% share of global clinical trial activity in 2021

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Canada accounts for 3.8% share of global clinical trial activity in 2021

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France accounts for 3.9% share of global clinical trial activity in 2021